Yes, it is possible to build a tolerance to Cenforce 100 over time, although this doesn't happen to everyone. Tolerance means the medication may become less effective after prolonged use, requiring higher doses to achieve the same results. This can happen due to changes in your body’s response to sildenafil, the active ingredient in Cenforce 100. However, increasing the dosage without medical advice can lead to serious side effects. If you notice reduced effectiveness, it’s important to talk to a healthcare provider. They may recommend lifestyle changes, adjusting the dosage, or exploring alternative treatments. Regular monitoring ensures safe and effective use.